Publications

Selected Highlights

For full list of publications see PubMed
* denotes equal contributions

ENPP1 is an innate immune checkpoint of the anticancer cGAMP–STING pathway in breast cancer
Songnan Wang, Volker Böhnert, Alby J. Joseph, Valentino Sudaryo, Gemini Skariah, Jason T. Swinderman, Feiqiao B. Yu, Vishvak Subramanyam, Denise M. Wolf, Xuchao Lyu, Luke A. Gilbert, Laura J. van’t Veer, Hani Goodarzi, and Lingyin Li
Proc. Nat. Acad. Sci. 2023
PMID: 38117852 DOI: 10.1073/pnas.2313693120

Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
Xueli Cao*, Yu Xiao*, Erin Huiting*, Xujun Cao, Dong Li, Jie Ren, Iana Fedorova, Hao Wang, Linlin Guan, Yu Wang, Lingyin Li, Joseph Bondy-Denomy, Yue Feng
Mol. Cell 2023
PMID: 38103556 DOI: 10.1016/j.molcel.2023.11.026

Discovery of VH domains that allosterically inhibit ENPP1
Paige E. Solomon, Colton J. Bracken, Jacqueline A. Carozza, Haoqing Wang, Elizabeth P. Young , Alon Wellner, Chang C. Liu, E. Alejandro Sweet-Cordero, Lingyin Li, James A. Wells
Nat. Chem. Biol. 2023
PMID: 37400538 DOI: 10.1038/s41589-023-01368-5

ENPP1's regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling
Jacqueline A. Carozza*, Anthony F. Cordova*, Jenifer Brown , Yasmeen AlSaif , Volker Böhnert , Xujun Cao , Rachel Mardjuki , Gemini Skariah. Daniel Fernandez , Lingyin Li
Proc. Nat. Acad. Sci. 2022
PMID: 35588451 DOI: 10.1073/pnas.2119189119

LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP
Lauren J. Lahey, Rachel E. Mardjuki, Xianlan Wen, Gaelen T. Hess, Christopher Ritchie, Jacqueline A. Carozza, Volker Böhnert, Merritt Maduke, Michael C. Bassik, Lingyin Li
Mol. Cell 2020
PMID: 33171122 DOI: 10.1016/j.molcel.2020.10.021

Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP
Jacqueline A. Carozza, Jenifer A Brown, Volker Böhnert, Daniel Fernandez, Yasmeen AlSaif, Rachel E Mardjuki, Mark Smith, Lingyin Li
Cell Chem. Biol. 2020
PMID: 32726585 DOI: 10.1016/j.chembiol.2020.07.007