Publications

Selected Highlights

For full list of publications see PubMed
* denotes equal contributions

PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity
Wei Wei, Xuchao Lyu, Andrew L Markhard, Sipei Fu, Rachel E Mardjuki, Peter E Cavanagh, Xianfeng Zeng, Jakub Rajniak, Nannan Lu, Shuke Xiao, Meng Zhao, Maria Dolores Moya-Garzon, Steven D Truong, Jonathan Chiu-Chun Chou, Lianna W Wat, Saranya Chidambaranathan-Reghupaty, Laetitia Coassolo, Duo Xu, Fangfang Shen, Wentao Huang, Cuauhtemoc B Ramirez, Cholsoon Jang, Lingyin Li, Katrin J Svensson, Michael A Fischbach, Jonathan Z Long
Nature 2024
PMID: 39112712 DOI: 10.1038/s41586-024-07801-6

PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection
Christopher Ritchie, Lingyin Li
Mol. Cell 2024
PMID: 38917796 DOI: 10.1016/j.molcel.2024.06.001

Identification of the extracellular membrane protein ENPP3 as a major cGAMP hydrolase and innate immune checkpoint
Rachel Mardjuki, Songnan Wang, Jacqueline Carozza, Bahar Zirak, Vishvak Subramanyam, Gita Abhiraman, Xuchao Lyu, Hani Goodarzi, Lingyin Li
Cell Rep. 2024
PMID: 38749434 DOI: 10.1016/j.celrep.2024.114209

Stimulating STING for cancer therapy: Taking the extracellular route
Lingyin Li
Cell Chem. Biol. 2024
PMID: 38723635 DOI: 10.1016/j.chembiol.2024.04.004

ENPP1 is an innate immune checkpoint of the anticancer cGAMP–STING pathway in breast cancer
Songnan Wang, Volker Böhnert, Alby J. Joseph, Valentino Sudaryo, Gemini Skariah, Jason T. Swinderman, Feiqiao B. Yu, Vishvak Subramanyam, Denise M. Wolf, Xuchao Lyu, Luke A. Gilbert, Laura J. van’t Veer, Hani Goodarzi, and Lingyin Li
Proc. Nat. Acad. Sci. 2023
PMID: 38117852 DOI: 10.1073/pnas.2313693120

Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
Xueli Cao*, Yu Xiao*, Erin Huiting*, Xujun Cao, Dong Li, Jie Ren, Iana Fedorova, Hao Wang, Linlin Guan, Yu Wang, Lingyin Li, Joseph Bondy-Denomy, Yue Feng
Mol. Cell 2023
PMID: 38103556 DOI: 10.1016/j.molcel.2023.11.026

Discovery of VH domains that allosterically inhibit ENPP1
Paige E. Solomon, Colton J. Bracken, Jacqueline A. Carozza, Haoqing Wang, Elizabeth P. Young , Alon Wellner, Chang C. Liu, E. Alejandro Sweet-Cordero, Lingyin Li, James A. Wells
Nat. Chem. Biol. 2023
PMID: 37400538 DOI: 10.1038/s41589-023-01368-5

ENPP1's regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling
Jacqueline A. Carozza*, Anthony F. Cordova*, Jenifer Brown , Yasmeen AlSaif , Volker Böhnert , Xujun Cao , Rachel Mardjuki , Gemini Skariah. Daniel Fernandez , Lingyin Li
Proc. Nat. Acad. Sci. 2022
PMID: 35588451 DOI: 10.1073/pnas.2119189119