Publications

Selected Highlights

For full list of publications see PubMed
* denotes equal contributions

ENPP1 inhibitor with ultralong drug-target residence time as an innate immune checkpoint blockade cancer therapy
Songnan Wang*, Randolph M. Johnson*, Jacqueline A. Carozza, Daniel Fernandez, Jan Scicinski, Neil A. Verity, Rachel Mardjuki, Xujun Cao, Yingjie Guo, Jacqueline Papkoff, Nigel Ray, Lingyin Li
Cell Rep. Med. 2025
DOI: 10.1016/j.xcrm.2025.102336

Cysteine allostery and autoinhibition govern human STING oligomer functionality
Rebecca Chan*, Xujun Cao*, Sabrina L. Ergun, Evert Njomen, Stephen R. Lynch, Christopher Ritchie, Benjamin Cravatt, Lingyin Li
Nat. Chem. Biol. 2025
DOI: 10.1038/s41589-025-01951-y

A cGAMP-Containing Hydrogel for Prolonged SARS-CoV-2Receptor-Binding Domain Subunit Vaccine ExposureInduces a Broad and Potent Humoral Response
Volker Böhnert, Emily C. Gale, Lauren J. Lahey, Jerry Yan, Abigail E. Powell, Ben S. Ou, Jacqueline A. Carozza, Lingyin Li, Eric A. Appel
Adv. Nanobiomed. Res 2024
DOI: 10.1002/anbr.202400077

PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity
Wei Wei, Xuchao Lyu, Andrew L Markhard, Sipei Fu, Rachel E Mardjuki, Peter E Cavanagh, Xianfeng Zeng, Jakub Rajniak, Nannan Lu, Shuke Xiao, Meng Zhao, Maria Dolores Moya-Garzon, Steven D Truong, Jonathan Chiu-Chun Chou, Lianna W Wat, Saranya Chidambaranathan-Reghupaty, Laetitia Coassolo, Duo Xu, Fangfang Shen, Wentao Huang, Cuauhtemoc B Ramirez, Cholsoon Jang, Lingyin Li, Katrin J Svensson, Michael A Fischbach, Jonathan Z Long
Nature 2024
PMID: 39112712 DOI: 10.1038/s41586-024-07801-6

PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection
Christopher Ritchie, Lingyin Li
Mol. Cell 2024
PMID: 38917796 DOI: 10.1016/j.molcel.2024.06.001

Identification of the extracellular membrane protein ENPP3 as a major cGAMP hydrolase and innate immune checkpoint
Rachel Mardjuki, Songnan Wang, Jacqueline Carozza, Bahar Zirak, Vishvak Subramanyam, Gita Abhiraman, Xuchao Lyu, Hani Goodarzi, Lingyin Li
Cell Rep. 2024
PMID: 38749434 DOI: 10.1016/j.celrep.2024.114209

Stimulating STING for cancer therapy: Taking the extracellular route
Lingyin Li
Cell Chem. Biol. 2024
PMID: 38723635 DOI: 10.1016/j.chembiol.2024.04.004

ENPP1 is an innate immune checkpoint of the anticancer cGAMP–STING pathway in breast cancer
Songnan Wang, Volker Böhnert, Alby J. Joseph, Valentino Sudaryo, Gemini Skariah, Jason T. Swinderman, Feiqiao B. Yu, Vishvak Subramanyam, Denise M. Wolf, Xuchao Lyu, Luke A. Gilbert, Laura J. van’t Veer, Hani Goodarzi, and Lingyin Li
Proc. Nat. Acad. Sci. 2023
PMID: 38117852 DOI: 10.1073/pnas.2313693120

Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
Xueli Cao*, Yu Xiao*, Erin Huiting*, Xujun Cao, Dong Li, Jie Ren, Iana Fedorova, Hao Wang, Linlin Guan, Yu Wang, Lingyin Li, Joseph Bondy-Denomy, Yue Feng
Mol. Cell 2023
PMID: 38103556 DOI: 10.1016/j.molcel.2023.11.026